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A true plateau is when weight stays about the same for an extended period, even though treatment and habits have not changed
Consistently, compared with placebo, more participants receiving any of the three tirzepatide doses had reductions in body weight of at least 5%, 10% or 15% (ESM Table 2)
However, direct reports of altered libido remain outside the scope of most published trial data
The clinical significance of this effect is not fully characterized, but some providers recommend that women on oral contraceptives switch to a non-oral method (patch, ring, IUD, implant) when starting GLP-1 therapy, or use backup contraception during the titration period