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Second, dual checkpoint blockade: BsAbs can concurrently inhibit two inhibitory immune checkpoints (for example, programmed cell death protein 1 (PD-1)/cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) or PD-1/T-cell immunoglobulin and mucin-domain containing-3 (TIM-3)), thereby synergistically releasing immunosuppressive signaling within the TME and augmenting T-cell-mediated antitumor responses [28]
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