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DDP-4 is reduced, allowing GLP-1 to remain in the plasma longer[6]
2d and e)
That is, statistically significant improvements in important domains of patient health and function were observed with vutrisiran compared to placebo
The glucagon component can also cause transient increases in heart rate and blood glucose, effects that do not occur with amylin-based compounds
These symptoms improve with continuous use, as only 3% and 9% of patients reported nausea with the long- or short-acting GLP-1RA after 6 months of use, respectively (72)
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