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322 Likewise, blocking mitophagy through agents such as chloroquine compromises mitochondrial function, enhancing the efficacy of targeted therapies and preventing relapse 321,322 Recognizing the inherent heterogeneity and adaptability of plastic tumor cells, combination therapies are increasingly emphasized to achieve durable responses

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Second, EtOH exposure, especially when chronic, reduces the antioxidant capacity of the liver and blood, as reflected by decreased levels of antioxidants (e.g