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To date, there are no known therapies that can alter the progression of KOA or prevent its occurrence [6]

Regulatory warnings in several countries 3

Which GLP-1 agonist is approved for weight loss

Often referred to as the master antioxidant, it plays a critical role in protecting cells from oxidative stress, supporting detoxification, and maintaining overall cellular health

These include Alzheimers Disease where neuroprotective effects are under investigation followed by stroke under similar notion (125) Futhermore, in non-alcoholic fatty liver disease (NAFLD) they show evidence of improved liver histology and hepatic steatosis (126) in PCOS they may help in regulation of weight, reproductive and metabolic parameters simultaneously (127) GLP1-Ras are also under study with their ability to modulate the hemodynamic and inflammatory pathways to treat CKD (128) and Heart failure (129)