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A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans
However, iron overload in patients with hemochromatosis results in excessive PS externalization and calpain activation in RBCs [83]
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In the SURMOUNT-1 trial, tirzepatide produced average body-weight losses of 15.0% at 5 mg, 19.5% at 10 mg, and 22.5% at 15 mg over 72 weeks, compared with 3.1% for placebo (Jastreboff et al., NEJM 2022)
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