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Gut dysbiosis is strongly associated with the development of ACM (16)

As a result, the skin loses its radiance and becomes dull

Furthermore, the asymptomatic patients with H

The increased diversity of the gut microbiota significantly correlates with the sparing of the hypothalamic microstructure in obese and non-obese individuals [44] Furthermore, in animal models, the gut microbiota modulates hypothalamic gene expression, neuropeptide secretion, neurotransmitter levels, and neuronal activity [45, 46]

prolyl endopeptidase), contains a number of exopeptidases, including quiescent cell proline dipeptidase (QPP, a.k.a