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GLP-1RAs work in a similar way to glucagon-like peptide-1 (a natural peptide hormone produced by cells in the intestine and in part of the brain), regulating blood sugar levels and appetite

These medicines include semaglutide (Ozempic, Wegovy, Rybelsus), liraglutide (Victoza, Saxenda), dulaglutide (Trulicity), and tirzepatide (Mounjaro)though tirzepatide is technically a dual GIP/GLP-1 receptor agonist rather than a pure GLP-1 agonist

Even moving from above average to high provided significant longevity gains