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This gradual increase helps minimize potential side effects, such as nausea
In the pathology of RA, IL-6 can stimulate pannus formation through increased vascular endothelial growth factor expression and increase bone resorption as a result of osteoclastogenesis, as well as oxidative stress in leukocytes
This contrasts with oral semaglutide, where adherence to the strict fasting protocol is essential for achieving therapeutic drug levels, and where deviations from the protocol (such as taking the medication with food or excessive water) can substantially reduce efficacy
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Semaglutide for reducing the risk of major adverse cardiovascular events in people with cardiovascular disease and overweight or obesity (GID-TA11544)
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