P (03) 9417 1555 [email protected] www.winnettspecialistgroup.com.au Queens Terrace, 382 Victoria Parade, East Melbourne 3002 Sources: 2* EASO 2024 Is coming off semaglutide slowly the key to preventing weight regain
"I know patients and clinicians are experimenting with less frequent dosing strategies to see if they can still maintain their weight but not necessarily in formal studies," she said
When GLP-1 works well, its easier to: Eat normal-sized portions Avoid constant snacking Keep blood sugar more stable When GLP-1 is not as effective, it can be harder to: Stop eating once you start Say no to cravings Stay in a calorie deficit long enough to lose weight Modern weight-loss treatments based on GLP-1 are built on this idea: instead of fighting hunger with willpower, they target the hormone that drives those hunger signals in the first place
The injectable obesity medications Semaglutide 2.4 mg, a selective GLP-1 receptor agonist, produces robust and durable weight loss of approximately 1516% over 68 weeks ( Tirzepatide, a dual gastric inhibitory polypeptide (GIP)/GLP-1 receptor agonist, delivers even greater weight loss, exceeding 20% at the highest dose in pivotal trials ( Retatrutide, a triple agonist targeting GIP, GLP-1, and glucagon receptors, represents a further step in efficacy, with 24.2% weight loss achieved within 48 weeks in phase 2 studies ( Survodutide, an oxyntomodulin analogue, achieved clinically meaningful weight loss ( Table 2
More people on tirzepatide also reached higher weightloss targets, such as 15% or more
