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The ASTRAAS trial (NCT04714320) evaluated changes in SBP from baseline to day 85 as the primary endpoint, whereas the ASTRAAS-HF trial (NCT04836182) investigated whether IONIS-AGT-LRx could serve as an adjunct therapy to standard treatment in patients with HFrEF
For those who have considered older medications like phentermine alongside semaglutide , the GLP-1 class has fundamentally changed expectations for what medication-assisted weight loss can achieve
Wiley et al., 2013
Some agents (Wegovy, Saxenda) are also approved for weight management in adolescents aged 12 and older
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