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When side effects occur, they are usually mild and temporary

Another challenge concerns the prevalence of epistatic interactions within stress-responsive regulatory networks

Higher cellular NAD+ was reported in preclinical work

Foundational work from the de Keizer laboratory (Baar et al., Cell, 2017) reported that the peptide perturbs the FOXO4-p53 association, leading to p53 nuclear exclusion and apoptosis that appeared preferential to senescent cells in cultured cells and aged mouse models

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