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In males, fertility depends on spermatogenesis, transport, and seminal fluid factors secreted by the prostate and seminal vesicles

In our experience and from the information presented in this review, IGF-1 acts as the cornerstone maintaining homeostasis in this system

Nevertheless, some of them may be involved in toxic effects of VPA, either in patients on chronic dosing or after an acute overdose

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These reactive metabolic by-products lead to cellular damage by promiscuously reacting with nucleic acids, proteins, and membrane lipids