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But participants assigned to higher maintenance doses of 4 mg, 8 mg, or 12 mg were started at either 2 mg or 4 mg, then escalated every four weeks
Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: a meta-analysis
The simultaneous activation of GIP and GLP-1 receptors may have central synergistic effects on appetite control, greater than selective GLP-1 receptor agonists [55], although preliminary studies do not support this hypothesis [56]
The gradual dose escalation strategy specifically aims to improve tolerability by allowing the digestive system to adjust to the medication's effects on gastric emptying and satiety signaling
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