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Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M

They draw water into the bowel, softening stools and increasing frequency Bulk-forming laxatives (ispaghula husk, methylcellulose) work similarly to dietary fibre and are generally suitable for long-term use, but should be avoided if you have severe bloating or suspected impaction Stimulant laxatives (senna, bisacodyl) should be reserved for short-term use when other measures fail Rectal treatments (glycerol suppositories, small-volume enemas) can provide rapid relief for occasional constipation Establishing a regular toilet routine can be beneficial

Long-term experiment Condition: 252/60%RH5%RH for 24 consecutive months

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The National Health and Nutrition Examination Survey estimated that up to 20% of adults over 50 may have borderline B12 deficiency