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Discrete choice experiments can formalize the trade-offs patients and clinicians routinely makebetween expected weight loss, chances of conception, adverse effects, out-of-pocket costs, and the possibility of post-discontinuation regainso that Evidence-to-Decision processes can incorporate empirically derived weights rather than implicit assumptions
The question is what comes next
The honest framing right now: encouraging, but not yet established for this population
GLP-1 receptor agonists carry a small increased risk of pancreatitis (Faillie et al., JAMA Internal Medicine 2014)
Active nausea or reflux indicates that gastric emptying is actively delayed, which severely increases aspiration risks and heavily influences whether your care team will choose to pause the medication
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