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Fen-phen crashed and burned after it was found to cause serious cardiovascular problems
Mechanisms deciphered in these studies indicate that the interaction between serotonin and GLP-1 in the hindbrain increases proopiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) neuron activity, leading to induction of satiety signals and suppression of neuropeptide Y/agouti-related peptide (NPY/AgRP) neuron activity, which in turn suppresses hunger
Thats not sustainable
10.1542/peds.2007-2361 82 KatoY.YokokuraM.IwabuchiT.MurayamaC.HaradaT.GotoT.et al (2023)
The Gold Standard for Cranial Nerves: EYEBOX Assessment The brain controls eye movement through a complex network involving multiple cranial nerves (III, IV, and VI)
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