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The anti-AS effects of GLP-1RAs include the regulation of inflammation (109), reduction of intima-media thickening (120), improvement of blood lipid profile (121), and regulation of endothelial dysfunction (122)

In the treatment-policy estimand analysis, at week 26 oral semaglutide (1.2% mean A1C reduction from baseline) met criteria for noninferiority when compared with liraglutide (1.1% mean A1C reduction from baseline) and met criteria for superiority when compared with placebo (0.2% mean A1C reduction from baseline

After stopping weight loss medications, patients typically regain about two-thirds of the weight they lost within a year

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However, excessive exercise without adequate recovery can increase oxidative stress, so balance is key