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10.1210/en.2017-03172 90
GLP-1 receptor agonist medicationslike Ozempic, Rybelsus, and Wegovyimprove the bodys natural insulin production. Diabetic patients treated with these medications have found another side effect: weight loss
These GLP-1 medications, as theyre commonly known, cause the same effects
Both glycerol and fatty-acid release can be quantified in adipocytes or ex vivo adipose tissue, but measured values are affected by reuptake, re-esterification, substrate binding, sampling time, and nonlinear accumulation
Mathematical modelling suggests dosing every other week might retain 75% of effectiveness, but patient reports indicate noticeable increases in hunger and appetite during off weeks
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