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Ceruloplasmin (CP) is a ferroxidase that is mainly found in a GPI-anchored form on astrocytes, converting toxic Fe 2+ to non-toxic Fe 3+ , physically associating with FPN1 to facilitate iron efflux from central nervous system cells, and inhibiting Fe 2+ -mediated lipid peroxidation by reducing the presence of highly reactive Fe 2+ (54, 55)
26 However, in a 5-year follow-up of a subset of these patients without hypertension at the start of the study, there was no association between the development of hypertension and sleep apnea after accounting for body mass index (BMI), suggesting this association may instead be caused by obesity
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Thus, they are attractive anticancer targets
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