Indications and Uses Semaglutide is prescribed for different purposes, primarily focusing on managing type 2 diabetes and promoting weight loss
At the same time, it is important to acknowledge the limitations of pivotal trials such as STEP and SELECT, whose generalisability is constrained by relatively short follow-up, notable dropout rates, and the predominance of Western cohorts
This is exactly where peptide research becomes relevant
In fact, as outlined above, HF is even more prevalent amongst people with obesity than amongst those with type 2 diabetes, and the consequences of excess body weight (i.e., adipose tissue) most likely play direct and indirect key roles in the development of HF
This was paralleled by the accumulation of glucose-6-phosphate (6P) in steady state GSH-deficient FoB (Supplementary Fig