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Research Significance
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[9] Visual disturbances have been reported in patients with Leber hereditary optic neuropathy, and rapid B12 administration may precipitate optic nerve atrophy in this genetically predisposed population, mandating extreme caution or alternative therapy
Clinical trials in patients with retinitis pigmentosaa hereditary retinal dystrophy causing progressive vision lossshowed positive clinical effects in 90% of treated cases
[61] Cyanide poisoning [edit] For cyanide poisoning, a large amount of hydroxocobalamin may be given intravenously and sometimes in combination with sodium thiosulfate
