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IGF-1 has been shown to promote neuroprotection by preventing neuronal loss and stimulating cell survival
The 39 amino acid sequence of tirzepatide shares similarity with that of GIP, GLP-1 and exendin-4 and is characterized by an acyl chain attached to the lysine residue at position 20 contributing to albumin binding and half-life extension to 5 days [41]
Medications such as semaglutide and liraglutide have been noted to provide benefits, including improved glycemic control, weight loss, and a reduction in cardiovascular risk
Frameworks To Consider For Long Term Use and Offboarding Several professional bodies have developed frameworks to guide clinicians in supporting patients who want to consider long term use or discontinuing GLP-1s altogether
