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Sihvola E, Rose R, Dick D, Pulkkinen L, Marttunen M, Kaprio J (2008) Early-onset depressive disorders predict the use of addictive substances in adolescence: a prospective study of adolescent finnish twins

The TRIUMPH-4 trial protocol provides the best reference for effective dosing : Weeks 1-4: 2 mg once weekly (starting dose) Weeks 5-8: 4 mg once weekly Weeks 9-12: 6 mg once weekly Weeks 13-16: 8 mg once weekly Week 17+: 9 mg or 12 mg once weekly (maintenance dose) The escalation happens every 4 weeks, which is slightly faster than many tirzepatide protocols

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It may be considered as a supportive option for inflammation, recovery, and wellness goals, but results vary