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Direct the water against the inner wall of the peptide vial as it is injected never onto the lyophilized cake, since direct impact foams the solution and damages peptide structure at the air-water interface
However, given the short half-lives of sitagliptin and exenatide, the impact of the lack of a washout period was likely not clinically relevant (55, 56)
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This study demonstrated that direct contact between Th17 T lymphocytes and oligodendrocytes induces oligodendrocyte stress, reduces myelinaton, and increases cell death
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