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Two-thirds of weight regain after bariatric surgery can be safely lost with GLP1-RAs
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The absence of such evidence means that healthcare professionals cannot reliably predict how these drugs might interact, whether they would provide additive benefits, or what adverse effects might emerge from their concurrent use
The largest psychiatric safety meta-analysis to date found that GLP-1 medications were not associated with increased risk of serious psychiatric adverse events overall ( Pierret et al., JAMA Psychiatry, 2025 ), and a post-hoc analysis of the major semaglutide weight management trials found no differences in depression, suicidal ideation, or suicidal behavior compared to placebo ( Wadden et al., JAMA Internal Medicine, 2024 )
Clinical trials have shown that topical application can improve skin density, reduce fine lines, enhance clarity, and increase overall skin thickness
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