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As a control for the effect of weight loss, a vehicle (PBS)-treated group was switched to standard diet to achieve the same weight range and the same percentage weight loss within the same time frame as those receiving semaglutide/BI8271
References [1] Lefkowitz, R
Diabetes Obes Metab 25(6):14951502
Current users of compounded or custom-mixed drugs were more likely to have switched from brand-name medications than vice versa (35% vs 10%), with cost or insurance coverage cited as the primary reason by 66% of those who switched to compounded versions
Using ALT ULN of 33 U/L and TB ULN of 1.25 mg/dL resulted in identification of 23 additional cases in Hy's Law quadrant (33.3% increase) and 828 additional cases (86.3% increase) in Temple's Corollary quadrant compared to using trial provided ULNs
