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While GLP-1 receptors are expressed on immune cells, there is no clear indication that semaglutide triggers new autoimmune conditions or worsens existing disease activity in most patients

So when these medications reduce food cravings, they might also dull the drive for other types of dependence-related behaviors

The transition to the 1.7 mg dose involves a significant increase in systemic drug exposure compared to the previous 1 mg dose, which requires careful monitoring for adverse events, particularly those affecting the gastrointestinal system