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Cardiometabolic Improvements Weight loss was accompanied by clinically meaningful improvements across several cardiovascular risk markers, including reductions in: Waist circumference (mean reduction of approximately 24.1 cm at the highest dose) Non-HDL cholesterol Triglycerides Systolic blood pressure High-sensitivity C-reactive protein (hsCRP) a marker of inflammation These findings are particularly relevant for patients with obesity who also live with cardiometabolic conditions, where systemic risk reduction is as important as the weight loss itself

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[38] noted GLP-1 binds to receptors on vagal afferent neurons, which decreased postprandial pancreatic digestive enzyme secretion

To establish a CFU count, 100 l of homogenized suspension from each well was added to 900 l of 1 PBS (final volume 1 ml)