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Coverage of each individual strain is assumed if the RP is higher than an antigen-specific positive bactericidal threshold (PBT), defined for each antigen on the basis of bactericidal activity of infant sera against a panel of 57 serogroup B strains

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As a key component of the inflammasome, the upregulation of NLRP3 activates caspase-1, promoting the production of pro-inflammatory cytokines such as IL-1 and IL-18, ultimately triggering pyroptosis in macrophages [142]