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Together, these hormones coordinate to regulate appetite, insulin and glucagon secretion, and nutrient metabolism, making them central to metabolic health

Retatrutide (Phase 2): A 48-week Phase 2 trial reported mean weight reductions of up to 24.2% from baseline at the highest dose

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After quality control of raw sequence reads with fastp [30], alignment to homo sapiens (GRCh38) or rattus norvegicus (GRCr8) reference genome for HCF and LMS datasets, respectively, was performed utilizing STAR [31]