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Patients who approach it as part of a comprehensive metabolic optimisation strategy consistently report sustained benefit
Extending these results to human cohorts will be important to determine the relevance of these findings
High-dose oral B12 (1,000 to 2,000 mcg daily) can actually correct deficiency even in some people with poor absorption, because a small percentage of B12 is absorbed passively (without intrinsic factor)
Numerous labs across the world have shown that inflammation causes reduced motivation and anhedonia, a core symptom of depression, by affecting the brains reward pathways
More substantial benefits including consistent deep sleep enhancement, comprehensive sleep architecture optimization, and robust recovery improvements typically develop over 1-4 weeks as circadian rhythms stabilize and sleep patterns normalize
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