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Local and systemic inflammation associated with dysbiosis appears to be at the center of the cascade of detrimental changes that impair body functioning and ultimately lead to clinical manifestations
ROS can induce autophagy through several mechanisms, including direct activation of AMP-activated protein kinase or inhibition of the mammalian target of rapamycin [163, 164]
This, in turn, led to a substantial reduction in energy metabolism in Huh7 and Hep3B cells
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