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GLP-1s work by suppressing appetite, slowing gastric emptying, and improving insulin sensitivity in ways that compound over months of consistent use
CM13 and CM14 had identical fragment ions at m/z 194 and 288 (Figure 5), indicating further oxidation at the monohydroxylated 5-ethyl side chain to form the ketone form (Scheme 1)
556 parent/fragment transitions corresponding to 95 peptides of 38 proteins were monitored by Selected Reaction Monitoring method (SRM) in a scheduled manner (Supplementary Data 1) using isolation windows of 0.7 m/z in Q1(parent) and 1.2 m/z in Q3 (fragment)
G.RoglianiP.et al (2016)
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