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Sonntag et al., Based on this review, we conclude that the perceived contradictory roles of growth hormone and insulin-like growth factor-1 in the genesis of the aging phenotype should not be interpreted as a controversy on whether growth hormone or insulin-like growth factor-1 increases or decreases life span but rather as an opportunity to explore the complex roles of these hormones during specific stages of the life span. Receptor Grade IGF-1 LR3 and Muscle Cells A study (7) was conducted on female murine models to identify the IGF-1 LR3 peptides potential in decreasing the action of myostatin