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These cardiovascular effects suggest potential applications in ischemic heart disease, peripheral vascular disease, and vascular injury, though clinical translation requires confirmation of effects in human subjects

Nutrients commonly associated with cognitive resilience include omega-3 fatty acids (particularly DHA), magnesium, vitamin D, zinc, polyphenols, and compounds such as curcumin and resveratrol, which may support mitochondrial function and neuronal signaling

Niacinamide and GHK-Cu help reduce inflammation and improve tolerance over time

CAFs, TAMs, MDSCs, exhausted T cells, extracellular matrix remodeling, and microbial communities collectively shape a permissive ecosystem that protects tumor cells from therapeutic eradication

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