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Tirzepatide went further, with up to 20.9% weight reduction in the SURMOUNT-1 trial (Jastreboff et al., N Engl J Med, 2022)

Diabetic peripheral neuropathy Peripheral nerve dysfunction occurs in about 50% of people with diabetes mellitus, and chronic neuropathic pain is present in about one-third of people with diabetic peripheral neuropathy (85)

Although we do not have clinical evidence regarding an impact on the effectiveness of oral contraceptives, there are some pharmacologic data to suggest that both tirzepatide (Mounjaro) and lixisenatide (Soliqua) may alter the absorption of oral contraceptives

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All other authors declare no competing interests