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TRIUMPH-1: Cardiometabolic Improvements (12mg, 80 weeks) Triglycerides: Reduced up to 41.0% Non-HDL cholesterol: Reduced up to 24.2% Systolic blood pressure: Reduced up to 12.3 mmHg Waist circumference: Reduced up to 24.1 cm hsCRP: Significant reduction (confirming systemic anti-inflammatory effect) TRIUMPH-1 vs

Healthcare providers should engage patients in shared decision-making regarding treatment duration, establishing clear goals at treatment initiation and regularly reassessing the need for continued therapy

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PloS one 4 , e6221, doi:10.1371/journal.pone.0006221 (2009)

Bioactivity is often reduced by neutralizing antibodies, which can be generated at different levels, depending on the immunogenicity of the protein drug (Rossman 2004)