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Behavioral and Neuroendocrine Pathways Clinical investigations propose that Melanotan 2 may modulate arousal-related neurosignaling through hypothalamic circuits sensitive to MC4R activity

2013 Sep] Author: Beghi E, Pupillo E, Bonito V, Buzzi P, Caponnetto C, Chi A, Corbo M, Giannini F, Inghilleri M, Bella VL, Logroscino G, Lorusso L, Lunetta C, Mazzini L, Messina P, Mora G, Perini M, Quadrelli ML, Silani V, Simone IL, Tremolizzo L

It is interesting to note that the positive effect of tirzepatide on body weight is associated with a significant improvement in quality of life and physical performance [50] and is independent of sex [51], baseline body mass index (BMI) [52] and potential side effects, predominantly gastrointestinal [53]

doi:10.1016/j.mrrev.2020.108320

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