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form of vitamin E not mentioned in the publication) for over two years significantly delayed functional decline determined by the (in)ability to perform basic activities of daily living and reduced the annual mortality rate in mild and moderate AD patients (111)

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52 Cellular stress, such as DNA damage, hypoxia, and oncogene activation, disturbs the interaction between p53 and MDM2 and inhibits p53 degradation, resulting in p53 accumulation