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Absorption is rapid, which is why IM is preferred for correcting a significant deficiency

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10.1002/ncp.10596 5 BenskyM

[1] Bi-Amino Injections clinical rationale draws on pharmacokinetic evidence that intravenous arginine produces a sharp plasma peak followed by biphasic clearance, whereas citrulline bypasses splanchnic arginase activity, undergoes efficient renal conversion back to arginine, and sustains substrate availability for nitric-oxide synthase several hours beyond the initial infusion

In some cases, healthcare providers may adjust the frequency, for example, some patients might be advised to take the injection twice weekly or once every two weeks, depending on their specific goals and how they respond to treatment