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"The growth hormone/IGF-1 axis is an attractive target for preserving muscle mass in cirrhosis, but the liver's dual role as both a GH effector organ and a metabolic clearance site means that any GH-axis intervention must account for the degree of hepatocellular dysfunction," according to the Endocrine Society's position statement on GH in chronic illness (Endocrine Society Clinical Practice Guideline, 2011)
[2] In other words, the pituitary continues to fire in bursts even when the GHRH signal is sustained, because somatostatin continues to impose its rhythm on top of that signal
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Next, these membranes were washed three times with TBST, and were incubate with the goat anti-rabbit IgG antibody (Abclonal, Wuhan, China) diluted 1: 10,000 for 1 h followed by triple washing with TBST
