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Data (Animal) In a combined fertility and embryofetal development study in rats, subcutaneous doses of 0.01, 0.03 and 0.09 mg/kg/day (0.1-, 0.4-, and 1.1-fold the MRHD) were administered to males for 4 weeks prior to and throughout mating and to females for 2 weeks prior to mating, and throughout organogenesis to Gestation Day 17

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It exhibits enhanced potency at the GIP receptor (approximately 8.9-fold greater than native GIP) while maintaining clinically relevant but relatively attenuated activation at GLP-1 and glucagon receptors

Hesperidin reverses perivascular adipose-mediated aortic stiffness with aging