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Background and aims: Recent advances in RNA sequencing techniques allow to identify tissue-specific alternative splicing and can thereby provide new insights into molecular mechanisms of energy metabolism
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Beneficial metabolic effects of insulin-like growth factor I in patients with severe insulin-resistant diabetes type A
In contrast, the gdh3 / gdh3 mutant showed overall higher concentrations of intracellular metabolites than the wild-type strain when grown in MM medium, except for 2-aminobutyrate and norvaline.When grown in a proline medium, the gdh3 / gdh3 mutant revealed a significantly higher concentration of glutamate family metabolites (e.g., glutamate, glutamine, and proline) than the wild-type, whilst asparagine, histidine, phenylalanine, valine, leucine, tyrosine, and aspartate family metabolites (e.g., aspartate, isoleucine, and threonine), as well as all saturated fatty acids detected, were at lower concentrations in the gdh3 / gdh3 mutant
In addition, increased permeability correlated with symptom severity in IBS-D (66)
