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This is, unfortunately, a common occurrence as we age Vegan or vegetarian diet as most B12 foods are from animal sources Excessive alcohol consumption Toxic metal exposure Some Auto-immune conditions Certain genetic polymorphism Some medications like antacids, anti-histamines, and some blood-sugar-lowering drugs

However, CsA exhibits significant intra- and inter-patient pharmacokinetic variabilities and has limited bioavailability

For instance: The results may not be right

Sig Transduct Target Ther 4 , 45 (2019)