maker of tirzepatide China Clears Eli Lilly's Weight Loss Drug Tirzepatide, Only For Diabetes FDA says the tirzepatide weight-loss

332,339 Similarly, agents that reverse HIF stabilization or inhibit mitochondrial metabolism in CAFs and CSCs are being explored to disrupt metabolic dependencies that underlie resistance

But this had major downsides

Cmaj (1985) 133:65963

| doi:10.1007/s10545-007-0666-z Constantin-Teodosiu D, Carlin JI, Cederblad G, Harris RC, Hultman E: Acetyl group accumulation and pyruvate dehydrogenase activity in human muscle during incremental exercise (1991) Acta Physiol Scand | doi:10.1111/j.1748-1716.1991.tb09247.x Diamanti K, Cavalli M, Pan G, et al.: Intra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type 2 diabetes

Understanding your genetic predispositions and clinical context may support a more informed conversation with your provider about risk-benefit tradeoffs