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In addition, mild to moderate gastrointestinal side effects were more frequent in the semaglutide-treated group compared to the placebo-treated group

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For Oil Red O (ORO) staining, BAT samples were rapidly frozen, cryo-sectioned, and treated with 4% paraformaldehyde for fixation

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This rapid absorption and clearance profile aligns with its physiological role as a mealtime hormone pramlintide is administered immediately before each major meal to replicate the prandial amylin release that is deficient in insulin-treated diabetes