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The pathophysiology is unclear, but risk factors are thought to be the same as the type 1 diabetic patients who rapidly improved A1c in the Diabetes Control and Complications Trial: long duration of diabetes mellitus, long duration of poor glycemic control, worse baseline level of DR prior to treatment and magnitude of reduction in A1c after treatment
If you have a liver disease, a kidney disease, or a seizure disorder, consult a healthcare practitioner prior to use
Patients should be advised about the urine discoloration (to avoid alarm) and counseled to report any persistent side effects
Knowing this temporary nature helps users push through the adjustment period rather than discontinuing prematurely
