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Medical treatments Powerful acids, like the kinds found in skin care products, can irritate the skin

Hydrolysis-prone sequences Sequences containing asparagine-glycine or glutamine-glycine are particularly vulnerable to deamidation, a base-catalyzed reaction that converts the amide to an acid

Both are commonly discussed in relation to anxiety, cognition, and neuroprotection

Shinya T, Yamaguchi K, Desaki Y, Yamada K, Narisawa T, Kobayashi Y (2014) Selective regulation of the chitin-induced defense response by the Arabidopsis receptor-like cytoplasmic kinase PBL27

When someone skips Steps 1 and 2, stacking can become an attempt to compensate for missing fundamentals