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The gene (MGLL) that encodes MGL is located on chromosome 3q21.3 and is composed of 12 exons that generate ten alternatively spliced mRNAs, that collectively encode nine distinct protein isoforms
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Khavinson V, Goncharova N, Lapin B
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While it has not been conclusively established whether this dysfunction is a cause or consequence of the pathological processes, growing evidence suggests that reduced proteasomal activity may contribute to the accumulation of toxic protein aggregates and the progression of neurodegeneration
